Entrez Summary: This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
EGF CA
Astacin
CUB
cEGF
GO Terms
high-density lipoprotein particle assembly
cartilage condensation
cell aggregation
plasma lipoprotein particle assembly
protein-lipid complex assembly
positive regulation of cartilage development
plasma lipoprotein particle organization
protein-lipid complex subunit organization
metallopeptidase activity
extracellular matrix disassembly
regulation of cartilage development
regulation of plasma lipoprotein particle levels
peptidase activity
metalloendopeptidase activity
vesicle
growth factor activity
cartilage development
cytokine activity
connective tissue development
skeletal system morphogenesis
ossification
extracellular matrix organization
extracellular structure organization
cellular component disassembly
skeletal system development
calcium ion binding
zinc ion binding
animal organ morphogenesis
Golgi apparatus
identical protein binding
proteolysis
positive regulation of developmental process
protein-containing complex assembly
extracellular space
positive regulation of multicellular organismal process
tissue development
protein-containing complex subunit organization
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739