BMP2
Gene Information
- Official Symbol: BMP2
- Official Name: bone morphogenetic protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 650
- UniProt: P12643
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016].
- UniProt Summary: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). {ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:3201241}.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| positive regulation of Wnt signaling pathway by BMP signaling pathway |
| negative regulation of calcium-independent cell-cell adhesion |
| endodermal-mesodermal cell signaling involved in heart induction |
| BMP receptor complex |
| regulation of calcium-independent cell-cell adhesion |
| endodermal-mesodermal cell signaling |
| heart induction |
| corticotropin hormone secreting cell differentiation |
| BMP signaling pathway involved in heart induction |
| cell proliferation involved in mesonephros development |
| thyroid-stimulating hormone-secreting cell differentiation |
| embryonic heart tube anterior/posterior pattern specification |
| phosphatase activator activity |
| mesenchymal cell proliferation involved in ureteric bud development |
| negative regulation of aldosterone biosynthetic process |
| negative regulation of aldosterone metabolic process |
| negative regulation of cortisol biosynthetic process |
| negative regulation of steroid hormone biosynthetic process |
| negative regulation of Wnt signaling pathway involved in heart development |
| negative regulation of glucocorticoid biosynthetic process |
| negative regulation of glucocorticoid metabolic process |
| negative regulation of insulin-like growth factor receptor signaling pathway |
| regulation of cortisol biosynthetic process |
| regulation of Wnt signaling pathway involved in heart development |
| bone mineralization involved in bone maturation |
| regulation of aldosterone biosynthetic process |
| regulation of aldosterone metabolic process |
| neuroendocrine cell differentiation |
| regulation of glucocorticoid biosynthetic process |
| regulation of glucocorticoid metabolic process |
| regulation of steroid hormone biosynthetic process |
| negative regulation of hormone biosynthetic process |
| cell proliferation involved in kidney development |
| positive regulation of osteoblast proliferation |
| positive regulation of odontogenesis |
| negative regulation of hormone metabolic process |
| BMP receptor binding |
| positive regulation of astrocyte differentiation |
| co-receptor binding |
| adenohypophysis development |
| telencephalon regionalization |
| pathway-restricted SMAD protein phosphorylation |
| negative regulation of alcohol biosynthetic process |
| regulation of odontogenesis of dentin-containing tooth |
| ossification involved in bone maturation |
| organ induction |
| mesenchymal cell proliferation |
| regulation of ketone biosynthetic process |
| bone maturation |
| negative regulation of cardiac muscle cell differentiation |
| pericardium development |
| retinol dehydrogenase activity |
| negative regulation of cardiocyte differentiation |
| animal organ maturation |
| positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| regulation of osteoblast proliferation |
| regulation of insulin-like growth factor receptor signaling pathway |
| negative regulation of steroid biosynthetic process |
| forebrain regionalization |
| atrioventricular valve morphogenesis |
| negative regulation of steroid metabolic process |
| atrioventricular valve development |
| regulation of odontogenesis |
| regulation of hormone biosynthetic process |
| regulation of astrocyte differentiation |
| positive regulation of p38MAPK cascade |
| developmental induction |
| cardiac epithelial to mesenchymal transition |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| negative regulation of cardiac muscle tissue development |
| positive regulation of cartilage development |
| positive regulation of phosphatase activity |
| endocardial cushion morphogenesis |
| regulation of animal organ formation |
| regulation of cardiac muscle cell differentiation |
| glandular epithelial cell differentiation |
| negative regulation of striated muscle cell differentiation |
| regulation of hormone metabolic process |
| positive regulation of bone mineralization |
| regulation of heart morphogenesis |
| regulation of p38MAPK cascade |
| pituitary gland development |
| regulation of pri-miRNA transcription by RNA polymerase II |
| positive regulation of glial cell differentiation |
| transforming growth factor beta receptor binding |
| endocardial cushion development |
| neuroepithelial cell differentiation |
| branching involved in ureteric bud morphogenesis |
| protein destabilization |
| positive regulation of biomineral tissue development |
| positive regulation of biomineralization |
| positive regulation of epithelial to mesenchymal transition |
| bone mineralization |
| negative regulation of striated muscle tissue development |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of muscle organ development |
| negative regulation of lipid biosynthetic process |
| regulation of cardiocyte differentiation |
| mesenchyme morphogenesis |
| negative regulation of muscle tissue development |
| heart valve morphogenesis |
| SMAD binding |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| negative regulation of muscle cell differentiation |
| SMAD protein signal transduction |
| positive regulation of dephosphorylation |
| positive regulation of osteoblast differentiation |
| regulation of pathway-restricted SMAD protein phosphorylation |
| positive regulation of fat cell differentiation |
| heart valve development |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| cardiac muscle tissue morphogenesis |
| renal tubule morphogenesis |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| epithelial to mesenchymal transition |
| regulation of cartilage development |
| regulation of alcohol biosynthetic process |
| regulation of bone mineralization |
| diencephalon development |
| nephron tubule development |
| regulation of cardiac muscle tissue development |
| renal tubule development |
| muscle tissue morphogenesis |
| positive regulation of animal organ morphogenesis |
| chondrocyte differentiation |
| odontogenesis of dentin-containing tooth |
| negative regulation of lipid metabolic process |
| regulation of epithelial to mesenchymal transition |
| kidney morphogenesis |
| positive regulation of ossification |
| ureteric bud development |
| mesonephric epithelium development |
| muscle organ morphogenesis |
| mesonephric tubule development |
| cardiac muscle cell differentiation |
| regulation of steroid biosynthetic process |
| BMP signaling pathway |
| negative regulation of small molecule metabolic process |
| mesonephros development |
| proteoglycan metabolic process |
| biomineralization |
| regulation of biomineral tissue development |
| biomineral tissue development |
| regulation of biomineralization |
| positive regulation of protein binding |
| positive regulation of endothelial cell proliferation |
| columnar/cuboidal epithelial cell differentiation |
| nephron epithelium development |
| regulation of striated muscle cell differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to BMP |
| cellular response to BMP stimulus |
| regulation of osteoblast differentiation |
| regulation of steroid metabolic process |
| regulation of gliogenesis |
| cardiocyte differentiation |
| odontogenesis |
| endocrine system development |
| regulation of fat cell differentiation |
| nephron development |
| Notch signaling pathway |
| osteoblast differentiation |
| regulation of endothelial cell proliferation |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| regulation of striated muscle tissue development |
| anatomical structure maturation |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of muscle cell differentiation |
| activation of MAPK activity |
| mesenchymal cell differentiation |
| morphogenesis of a branching epithelium |
| cardiac muscle tissue development |
| growth factor activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| morphogenesis of a branching structure |
| regulation of cellular ketone metabolic process |
| cartilage development |
| cytokine activity |
| negative regulation of cell-cell adhesion |
| negative regulation of canonical Wnt signaling pathway |
| regulation of phosphatase activity |
| positive regulation of Wnt signaling pathway |
| positive regulation of binding |
| regulation of lipid biosynthetic process |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| inner ear development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| striated muscle cell differentiation |
| negative regulation of Wnt signaling pathway |
| regulation of dephosphorylation |
| positive regulation of ERK1 and ERK2 cascade |
| anterior/posterior pattern specification |
| regulation of protein binding |
| mesenchyme development |
| ear development |
| connective tissue development |
| regulation of stress-activated MAPK cascade |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of stress-activated protein kinase signaling cascade |
| developmental maturation |
| muscle cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| telencephalon development |
| regulation of animal organ morphogenesis |
| positive regulation of MAP kinase activity |
| ossification |
| kidney development |
| negative regulation of cell adhesion |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| renal system development |
| regulation of protein stability |
| regulation of ERK1 and ERK2 cascade |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| urogenital system development |
| activation of protein kinase activity |
| regionalization |
| regulation of epithelial cell proliferation |
| signaling receptor binding |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| response to hypoxia |
| response to decreased oxygen levels |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| regulation of binding |
| in utero embryonic development |
| response to oxygen levels |
| forebrain development |
| glycoprotein metabolic process |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| gland development |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| morphogenesis of an epithelium |
| pattern specification process |
| positive regulation of neurogenesis |
| muscle structure development |
| protein heterodimerization activity |
| skeletal system development |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| sensory organ development |
| positive regulation of locomotion |
| cell population proliferation |
| tissue morphogenesis |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| cell surface |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| response to bacterium |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| brain development |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| head development |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| carbohydrate derivative metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8319
- Expression level (log2 read counts): -1.43
Expression Distribution
BMP2 Expression in NALM6 Cells: -1.43
