C12orf52

• Official Symbol: RITA1
• Official Name: RBPJ interacting and tubulin associated 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 84934
• UniProt: Q96K30
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 16069
• Expression level (log2 read counts): 4.74

Expression Distribution

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C12ORF52 Expression in NALM6 Cells: 4.74