C1QB
Gene Information
- Official Symbol: C1QB
- Official Name: complement C1q B chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 713
- UniProt: P02746
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016].
- UniProt Summary: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8337
- Expression level (log2 read counts): -3.59
C1QB Expression in NALM6 Cells: -3.59
