UniProt Summary: Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:17284679}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
G1 to G0 transition
cellular senescence
cell aging
anaphase-promoting complex-dependent catabolic process
aging
apical plasma membrane
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
central nervous system development
cell cycle process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
cell cycle
extracellular space
regulation of cell population proliferation
cellular response to stress
organic substance catabolic process
cellular catabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739