C7orf49
Gene Information
- Official Symbol: CYREN
- Official Name: cell cycle regulator of NHEJ
- Aliases and Previous Symbols: N/A
- Entrez ID: 78996
- UniProt: Q9BWK5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000269|PubMed:28959974}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15006
- Expression level (log2 read counts): 5.09
C7ORF49 Expression in NALM6 Cells: 5.09
