C7orf60
Gene Information
- Official Symbol: BMT2
- Official Name: base methyltransferase of 25S rRNA 2 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 154743
- UniProt: Q1RMZ1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S- adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000269|PubMed:29123071}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17497
- Expression level (log2 read counts): 2.52
C7ORF60 Expression in NALM6 Cells: 2.52
