C8G
Gene Information
- Official Symbol: C8G
- Official Name: complement C8 gamma chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 733
- UniProt: P07360
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011].
- UniProt Summary: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9645
- Expression level (log2 read counts): -2.08
C8G Expression in NALM6 Cells: -2.08
