UniProt Summary: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269|PubMed:15637807}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
CARD domain binding
negative regulation of I-kappaB kinase/NF-kappaB signaling
mitochondrial membrane
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of intracellular signal transduction
endoplasmic reticulum membrane
mitochondrion
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of intracellular signal transduction
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)