CALCR
Gene Information
- Official Symbol: CALCR
- Official Name: calcitonin receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 799
- UniProt: P30988
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HRM |
| 7tm 2 |
GO Terms
| calcitonin binding |
| calcitonin receptor activity |
| positive regulation of calcium ion import across plasma membrane |
| cross-receptor inhibition within G protein-coupled receptor heterodimer |
| amylin receptor complex 2 |
| amylin receptor complex 1 |
| amylin receptor complex 3 |
| amylin receptor activity |
| calcitonin gene-related peptide receptor activity |
| regulation of calcium ion import across plasma membrane |
| amylin receptor signaling pathway |
| calcitonin family receptor signaling pathway |
| positive regulation of protein kinase A signaling |
| regulation of protein kinase A signaling |
| positive regulation of calcium ion import |
| activation of adenylate cyclase activity |
| regulation of calcium ion import |
| response to amyloid-beta |
| positive regulation of calcium ion transport into cytosol |
| negative regulation of signaling receptor activity |
| positive regulation of calcium ion transmembrane transport |
| amyloid-beta binding |
| regulation of calcium ion transport into cytosol |
| positive regulation of peptidyl-serine phosphorylation |
| positive regulation of calcium ion transport |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of cation transmembrane transport |
| regulation of G protein-coupled receptor signaling pathway |
| response to glucocorticoid |
| cAMP-mediated signaling |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| response to corticosteroid |
| positive regulation of protein kinase B signaling |
| cyclic-nucleotide-mediated signaling |
| regulation of signaling receptor activity |
| positive regulation of transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of protein kinase B signaling |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| axon |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| regulation of metal ion transport |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| response to lipid |
| cellular homeostasis |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| positive regulation of transport |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dimethyl-Sulfoxide 1pc R03 exp120 | -2.25 |
| Cadmium 60μM R08 exp462 | -1.92 |
| LLY-283 2.6μM R06 exp290 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9781
- Expression level (log2 read counts): -7.68
Expression Distribution
CALCR Expression in NALM6 Cells: -7.68
