CASP4
Gene Information
- Official Symbol: CASP4
- Official Name: caspase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 837
- UniProt: P49662
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Peptidase C14 |
| CARD |
GO Terms
| inflammasome complex |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| positive regulation of tumor necrosis factor-mediated signaling pathway |
| cysteine-type endopeptidase activity involved in apoptotic process |
| CARD domain binding |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| cellular response to amyloid-beta |
| response to amyloid-beta |
| positive regulation of cytokine-mediated signaling pathway |
| execution phase of apoptosis |
| positive regulation of response to cytokine stimulus |
| regulation of tumor necrosis factor-mediated signaling pathway |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| cysteine-type endopeptidase activity |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of endopeptidase activity |
| regulation of response to cytokine stimulus |
| positive regulation of peptidase activity |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| response to endoplasmic reticulum stress |
| apoptotic signaling pathway |
| cellular response to peptide |
| positive regulation of proteolysis |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| response to peptide |
| inflammatory response |
| protein-containing complex |
| cellular response to organonitrogen compound |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| cellular response to nitrogen compound |
| positive regulation of cell death |
| regulation of proteolysis |
| innate immune response |
| positive regulation of hydrolase activity |
| apoptotic process |
| endoplasmic reticulum membrane |
| defense response to other organism |
| response to organonitrogen compound |
| endoplasmic reticulum |
| programmed cell death |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell death |
| cellular response to endogenous stimulus |
| mitochondrion |
| proteolysis |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18522
- Expression level (log2 read counts): 4.65
Expression Distribution
CASP4 Expression in NALM6 Cells: 4.65
