CASP5
Gene Information
- Official Symbol: CASP5
- Official Name: caspase 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 838
- UniProt: P51878
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Peptidase C14 |
| CARD |
GO Terms
| NLRP1 inflammasome complex |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| cysteine-type endopeptidase activity involved in apoptotic process |
| cysteine-type peptidase activity |
| substantia nigra development |
| execution phase of apoptosis |
| neural nucleus development |
| cellular response to mechanical stimulus |
| midbrain development |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| cysteine-type endopeptidase activity |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| response to mechanical stimulus |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| apoptotic signaling pathway |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| cellular response to external stimulus |
| positive regulation of proteolysis |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| regulation of proteolysis |
| brain development |
| positive regulation of hydrolase activity |
| head development |
| apoptotic process |
| central nervous system development |
| programmed cell death |
| cell death |
| response to abiotic stimulus |
| proteolysis |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.02μM R00 exp23 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16419
- Expression level (log2 read counts): -2.79
Expression Distribution
CASP5 Expression in NALM6 Cells: -2.79
