CCDC174

Entrez Summary: The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involved in RNA processing, translation, and nonsense-mediated mRNA decay. A mutation in this gene has been associated with infantile hypotonia with psychomotor retardation. [provided by RefSeq, Mar 2016].
UniProt Summary: Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-1.93

Global Fraction of Cell Lines Where Essential: 146/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	5/28
bone	4/26
breast	10/33
central nervous system	8/56
cervix	0/4
colorectal	9/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	5/21
liver	1/20
lung	19/75
lymphocyte	6/16
ovary	6/26
pancreas	5/24
peripheral nervous system	6/16
plasma cell	1/15
prostate	0/1
skin	4/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	2/29
uterus	2/5

Expression Distribution