UniProt Summary: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Cyclin N
GO Terms
cyclin-dependent protein kinase holoenzyme complex
cyclin-dependent protein serine/threonine kinase regulator activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
protein kinase activity
mitotic cell cycle phase transition
cell cycle phase transition
protein kinase binding
cell division
regulation of protein serine/threonine kinase activity
mitotic cell cycle process
mitotic cell cycle
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
cell cycle process
regulation of cell cycle
phosphorylation
cell cycle
regulation of protein phosphorylation
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739