UniProt Summary: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Pfam DomainsGO Terms
Pfam Domains
7tm 1
GO Terms
chemokine receptor binding
chemokine receptor activity
C-C chemokine receptor activity
chemokine binding
C-C chemokine binding
CCR chemokine receptor binding
chemokine-mediated signaling pathway
cellular response to chemokine
response to chemokine
calcium-mediated signaling
cell chemotaxis
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
external side of plasma membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
chemotaxis
taxis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cytokine-mediated signaling pathway
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
cell migration
cellular response to cytokine stimulus
localization of cell
cell motility
response to cytokine
chemical homeostasis
locomotion
G protein-coupled receptor signaling pathway
defense response
integral component of plasma membrane
movement of cell or subcellular component
homeostatic process
intracellular signal transduction
immune response
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)