CD40LG
Gene Information
- Official Symbol: CD40LG
- Official Name: CD40 ligand
- Aliases and Previous Symbols: N/A
- Entrez ID: 959
- UniProt: P29965
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T- cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250|UniProtKB:P27548, ECO:0000269|PubMed:1280226, ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}.
Pfam Domains GO Terms
Pfam Domains
| TNF |
GO Terms
| CD40 receptor binding |
| immunoglobulin secretion |
| somatic recombination of immunoglobulin genes involved in immune response |
| isotype switching |
| somatic diversification of immunoglobulins involved in immune response |
| regulation of immunoglobulin secretion |
| positive regulation of endothelial cell apoptotic process |
| positive regulation of interleukin-4 production |
| somatic recombination of immunoglobulin gene segments |
| immunoglobulin production involved in immunoglobulin mediated immune response |
| regulation of interleukin-4 production |
| tumor necrosis factor receptor binding |
| positive regulation of epithelial cell apoptotic process |
| positive regulation of interleukin-12 production |
| somatic diversification of immune receptors via germline recombination within a single locus |
| somatic cell DNA recombination |
| positive regulation of interleukin-10 production |
| somatic diversification of immunoglobulins |
| activation of JUN kinase activity |
| B cell proliferation |
| B cell activation involved in immune response |
| somatic diversification of immune receptors |
| regulation of endothelial cell apoptotic process |
| leukocyte cell-cell adhesion |
| regulation of interleukin-10 production |
| regulation of interleukin-12 production |
| T cell costimulation |
| lymphocyte costimulation |
| regulation of immunoglobulin production |
| positive regulation of JUN kinase activity |
| regulation of epithelial cell apoptotic process |
| JNK cascade |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| regulation of JUN kinase activity |
| positive regulation of T cell proliferation |
| leukocyte proliferation |
| stress-activated MAPK cascade |
| B cell differentiation |
| lymphocyte activation involved in immune response |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| platelet activation |
| positive regulation of JNK cascade |
| regulation of production of molecular mediator of immune response |
| stress-activated protein kinase signaling cascade |
| positive regulation of NF-kappaB transcription factor activity |
| B cell activation |
| activation of MAPK activity |
| regulation of T cell proliferation |
| immunoglobulin production |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| peptide secretion |
| cytokine activity |
| production of molecular mediator of immune response |
| regulation of JNK cascade |
| positive regulation of T cell activation |
| immunoglobulin mediated immune response |
| B cell mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| DNA recombination |
| regulation of leukocyte proliferation |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| cellular response to tumor necrosis factor |
| positive regulation of cell-cell adhesion |
| positive regulation of MAP kinase activity |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| lymphocyte mediated immunity |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| blood coagulation |
| coagulation |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| regulation of T cell activation |
| activation of protein kinase activity |
| leukocyte differentiation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| MAPK cascade |
| lymphocyte activation |
| signal transduction by protein phosphorylation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| regulation of protein secretion |
| regulation of immune effector process |
| wound healing |
| regulation of peptide secretion |
| regulation of body fluid levels |
| inflammatory response |
| cell-cell adhesion |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| cell population proliferation |
| hemopoiesis |
| response to wounding |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| DNA metabolic process |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| protein phosphorylation |
| regulation of transferase activity |
| negative regulation of cell death |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| response to cytokine |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| phosphorylation |
| defense response |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 19048
- Expression level (log2 read counts): -0.13
Expression Distribution
CD40LG Expression in NALM6 Cells: -0.13
