UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Pfam DomainsGO Terms
Pfam Domains
Cadherin C
Cadherin
GO Terms
integral component of presynaptic active zone membrane
integral component of postsynaptic specialization membrane
cell-cell adhesion mediated by cadherin
catenin complex
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GABA-ergic synapse
cytoskeletal protein binding
adherens junction organization
cell-cell junction assembly
cell-cell adherens junction
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
cell junction organization
cell-cell adhesion via plasma-membrane adhesion molecules
cadherin binding
glutamatergic synapse
cell-cell adhesion
cell surface
calcium ion binding
cell morphogenesis
cellular component morphogenesis
protein homodimerization activity
cell adhesion
biological adhesion
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739