CDK5R2
Gene Information
- Official Symbol: CDK5R2
- Official Name: cyclin dependent kinase 5 regulatory subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8941
- UniProt: Q13319
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activator of CDK5/TPKII.
Pfam Domains GO Terms
Pfam Domains
| CDK5 activator |
GO Terms
| superior olivary nucleus maturation |
| superior olivary nucleus development |
| protein kinase 5 complex |
| pons maturation |
| hindbrain maturation |
| central nervous system maturation |
| cyclin-dependent protein serine/threonine kinase activator activity |
| pons development |
| layer formation in cerebral cortex |
| positive regulation of calcium ion-dependent exocytosis |
| telencephalon glial cell migration |
| cerebral cortex radial glia guided migration |
| cerebral cortex radially oriented cell migration |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of cyclin-dependent protein kinase activity |
| glial cell migration |
| regulation of calcium ion-dependent exocytosis |
| cerebral cortex cell migration |
| positive regulation of regulated secretory pathway |
| telencephalon cell migration |
| forebrain cell migration |
| neural nucleus development |
| hippocampus development |
| positive regulation of exocytosis |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| cerebellum development |
| limbic system development |
| metencephalon development |
| cerebral cortex development |
| neuron migration |
| growth cone |
| anatomical structure maturation |
| hindbrain development |
| lipid binding |
| regulation of regulated secretory pathway |
| pallium development |
| gliogenesis |
| regulation of exocytosis |
| developmental maturation |
| telencephalon development |
| actin binding |
| neuron projection |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of cell cycle |
| forebrain development |
| positive regulation of secretion by cell |
| positive regulation of secretion |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| regulation of vesicle-mediated transport |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| brain development |
| regulation of secretion by cell |
| head development |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| cell migration |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of protein modification process |
| locomotion |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4291
- Expression level (log2 read counts): -2.08
Expression Distribution
CDK5R2 Expression in NALM6 Cells: -2.08
