CDK5RAP1
Gene Information
- Official Symbol: CDK5RAP1
- Official Name: CDK5 regulatory subunit associated protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51654
- UniProt: Q96SZ6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UPF0004 |
| TRAM |
| Radical SAM |
GO Terms
| N6-isopentenyladenosine methylthiotransferase activity |
| tRNA methylthiolation |
| positive regulation of translational fidelity |
| mitochondrial tRNA modification |
| mitochondrial RNA modification |
| mitochondrial tRNA processing |
| tRNA threonylcarbamoyladenosine metabolic process |
| mitochondrial RNA processing |
| positive regulation of mitochondrial translation |
| regulation of translational fidelity |
| regulation of mitochondrial translation |
| regulation of mitochondrial gene expression |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of cyclin-dependent protein kinase activity |
| mitochondrial RNA metabolic process |
| 4 iron, 4 sulfur cluster binding |
| tRNA modification |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of translation |
| tRNA processing |
| negative regulation of protein serine/threonine kinase activity |
| mitochondrial gene expression |
| positive regulation of cellular amide metabolic process |
| RNA modification |
| tRNA metabolic process |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| protein-containing complex binding |
| negative regulation of transferase activity |
| regulation of translation |
| ncRNA processing |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| cellular component |
| protein kinase binding |
| ncRNA metabolic process |
| regulation of protein serine/threonine kinase activity |
| posttranscriptional regulation of gene expression |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| regulation of neuron differentiation |
| brain development |
| head development |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of kinase activity |
| RNA processing |
| regulation of nervous system development |
| regulation of cell development |
| regulation of transferase activity |
| central nervous system development |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| mitochondrion |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3323
- Expression level (log2 read counts): 6.05
Expression Distribution
CDK5RAP1 Expression in NALM6 Cells: 6.05
