CDKN2D
Gene Information
- Official Symbol: CDKN2D
- Official Name: cyclin dependent kinase inhibitor 2D
- Aliases and Previous Symbols: N/A
- Entrez ID: 1032
- UniProt: P55273
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.
Pfam Domains GO Terms
Pfam Domains
| Ank 2 |
GO Terms
| cyclin D2-CDK4 complex |
| autophagic cell death |
| cyclin-dependent protein serine/threonine kinase inhibitor activity |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| response to vitamin D |
| negative regulation of cyclin-dependent protein kinase activity |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| DNA synthesis involved in DNA repair |
| negative regulation of response to DNA damage stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to vitamin |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| response to retinoic acid |
| DNA biosynthetic process |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| negative regulation of protein serine/threonine kinase activity |
| response to UV |
| cell cycle arrest |
| sensory perception of sound |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of cell cycle G1/S phase transition |
| sensory perception of mechanical stimulus |
| negative regulation of cell growth |
| negative regulation of mitotic cell cycle phase transition |
| response to nutrient |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| negative regulation of protein kinase activity |
| negative regulation of cell cycle phase transition |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of growth |
| negative regulation of endopeptidase activity |
| negative regulation of kinase activity |
| negative regulation of peptidase activity |
| mitotic cell cycle phase transition |
| negative regulation of transferase activity |
| cell cycle phase transition |
| negative regulation of mitotic cell cycle |
| response to light stimulus |
| negative regulation of cell cycle process |
| response to acid chemical |
| negative regulation of proteolysis |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of cell growth |
| response to radiation |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| negative regulation of hydrolase activity |
| protein kinase binding |
| response to nutrient levels |
| negative regulation of intracellular signal transduction |
| DNA repair |
| regulation of protein serine/threonine kinase activity |
| response to extracellular stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| regulation of growth |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| regulation of proteolysis |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to organic cyclic compound |
| sensory perception |
| regulation of transferase activity |
| negative regulation of cell death |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15334
- Expression level (log2 read counts): 3.52
Expression Distribution
CDKN2D Expression in NALM6 Cells: 3.52
