CFC1
Gene Information
- Official Symbol: CFC1
- Official Name: cripto, FRL-1, cryptic family 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55997
- UniProt: P0CG37
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
- UniProt Summary: NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. {ECO:0000269|PubMed:11062482}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4429
- Expression level (log2 read counts): -7.68
CFC1 Expression in NALM6 Cells: -7.68
