UniProt Summary: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Pfam DomainsGO Terms
Pfam Domains
ATP-gua Ptrans
ATP-gua PtransN
GO Terms
phosphagen metabolic process
phosphocreatine metabolic process
phosphocreatine biosynthetic process
phosphagen biosynthetic process
creatine kinase activity
creatine metabolic process
cellular modified amino acid biosynthetic process
kinase activity
cellular modified amino acid metabolic process
mitochondrial inner membrane
drug metabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
phosphorylation
organonitrogen compound biosynthetic process
ATP binding
small molecule metabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A