UniProt Summary: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
PMP22 Claudin
GO Terms
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
bicellular tight junction
structural molecule activity
cell-cell adhesion via plasma-membrane adhesion molecules
cell-cell adhesion
cell adhesion
biological adhesion
identical protein binding
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739