CLDN4
Gene Information
- Official Symbol: CLDN4
- Official Name: claudin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 1364
- UniProt: O14493
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013].
- UniProt Summary: Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O35054}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5726
- Expression level (log2 read counts): 1.3
CLDN4 Expression in NALM6 Cells: 1.3
