CMA1
Gene Information
- Official Symbol: CMA1
- Official Name: chymase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1215
- UniProt: P23946
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Pfam Domains GO Terms
Pfam Domains
| Trypsin |
GO Terms
| interleukin-1 beta biosynthetic process |
| interleukin-1 biosynthetic process |
| basement membrane disassembly |
| regulation of angiotensin levels in blood |
| angiotensin maturation |
| cytokine biosynthetic process |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin |
| interleukin-1 beta production |
| cytokine metabolic process |
| interleukin-1 production |
| basement membrane organization |
| regulation of systemic arterial blood pressure by renin-angiotensin |
| peptide hormone processing |
| regulation of systemic arterial blood pressure by hormone |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| endocrine process |
| peptide binding |
| serine-type peptidase activity |
| extracellular matrix disassembly |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| cellular response to carbohydrate stimulus |
| midbrain development |
| secretory granule |
| cellular glucose homeostasis |
| regulation of systemic arterial blood pressure |
| response to glucose |
| response to hexose |
| response to monosaccharide |
| cytokine production |
| protein processing |
| positive regulation of angiogenesis |
| serine-type endopeptidase activity |
| response to carbohydrate |
| regulation of blood pressure |
| positive regulation of vasculature development |
| glucose homeostasis |
| carbohydrate homeostasis |
| hormone metabolic process |
| protein maturation |
| regulation of angiogenesis |
| regulation of vasculature development |
| regulation of inflammatory response |
| extracellular matrix organization |
| collagen-containing extracellular matrix |
| extracellular structure organization |
| blood circulation |
| circulatory system process |
| cellular component disassembly |
| peptide metabolic process |
| regulation of hormone levels |
| brain development |
| cellular chemical homeostasis |
| regulation of defense response |
| head development |
| cellular amide metabolic process |
| cellular homeostasis |
| central nervous system development |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| chemical homeostasis |
| proteolysis |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| regulation of response to stress |
| response to oxygen-containing compound |
| extracellular space |
| homeostatic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| extracellular region |
| system process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pimelic-diphenylamide-106 5μM R00 exp28 | -1.93 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.565 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14508
- Expression level (log2 read counts): -4.6
Expression Distribution
CMA1 Expression in NALM6 Cells: -4.6
