COL4A5
Gene Information
- Official Symbol: COL4A5
- Official Name: collagen type IV alpha 5 chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 1287
- UniProt: P29400
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010].
- UniProt Summary: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12096
- Expression level (log2 read counts): 0.06
COL4A5 Expression in NALM6 Cells: 0.06
