CORO2B
Gene Information
- Official Symbol: CORO2B
- Official Name: coronin 2B
- Aliases and Previous Symbols: N/A
- Entrez ID: 10391
- UniProt: Q9UQ03
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in the reorganization of neuronal actin structure.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
| DUF1900 |
| DUF1899 |
GO Terms
| talin binding |
| regulation of glomerular filtration |
| vinculin binding |
| renal system process involved in regulation of blood volume |
| negative regulation of stress fiber assembly |
| negative regulation of actin filament bundle assembly |
| renal system process involved in regulation of systemic arterial blood pressure |
| cell-substrate adherens junction assembly |
| focal adhesion assembly |
| regulation of renal system process |
| adherens junction assembly |
| cell-substrate junction assembly |
| negative regulation of cell-substrate adhesion |
| regulation of stress fiber assembly |
| adherens junction organization |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| regulation of systemic arterial blood pressure |
| renal system process |
| cell-matrix adhesion |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| cell junction assembly |
| regulation of blood pressure |
| cell-substrate adhesion |
| negative regulation of establishment of protein localization |
| actin filament binding |
| regulation of cell-substrate adhesion |
| cell junction organization |
| actin cytoskeleton |
| regulation of actin filament organization |
| actin binding |
| negative regulation of cell adhesion |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| regulation of actin filament-based process |
| blood circulation |
| circulatory system process |
| focal adhesion |
| positive regulation of establishment of protein localization |
| actin cytoskeleton organization |
| regulation of body fluid levels |
| regulation of cytoskeleton organization |
| actin filament-based process |
| regulation of system process |
| regulation of cell adhesion |
| negative regulation of cellular component organization |
| regulation of cellular response to stress |
| regulation of establishment of protein localization |
| cell adhesion |
| biological adhesion |
| regulation of cellular component biogenesis |
| regulation of protein localization |
| cytoskeleton organization |
| regulation of organelle organization |
| regulation of response to stress |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Metformin 40μM R03 exp132 | -2.08 |
| Mubritinib 0.2μM R01 exp48 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11027
- Expression level (log2 read counts): 5.3
Expression Distribution
CORO2B Expression in NALM6 Cells: 5.3
