CPB2
Gene Information
- Official Symbol: CPB2
- Official Name: carboxypeptidase B2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1361
- UniProt: Q96IY4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}.
Pfam Domains GO Terms
Pfam Domains
| Peptidase M14 |
| Propep M14 |
GO Terms
| positive regulation of extracellular matrix constituent secretion |
| negative regulation of hepatocyte proliferation |
| negative regulation of plasminogen activation |
| regulation of extracellular matrix constituent secretion |
| negative regulation of fibrinolysis |
| regulation of fibrinolysis |
| regulation of hepatocyte proliferation |
| regulation of plasminogen activation |
| positive regulation of extracellular matrix organization |
| fibrinolysis |
| positive regulation of hemostasis |
| positive regulation of blood coagulation |
| positive regulation of coagulation |
| metallocarboxypeptidase activity |
| liver regeneration |
| negative regulation of protein maturation |
| negative regulation of protein processing |
| negative regulation of animal organ morphogenesis |
| regulation of extracellular matrix organization |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| positive regulation of wound healing |
| positive regulation of response to wounding |
| regulation of protein processing |
| regulation of protein maturation |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| negative regulation of wound healing |
| cellular response to monosaccharide stimulus |
| animal organ regeneration |
| regulation of blood coagulation |
| cellular response to carbohydrate stimulus |
| regulation of hemostasis |
| cell |
| regulation of coagulation |
| negative regulation of response to wounding |
| cellular glucose homeostasis |
| response to heat |
| regulation of complement activation |
| negative regulation of epithelial cell proliferation |
| liver development |
| hepaticobiliary system development |
| regulation of humoral immune response |
| response to glucose |
| regulation of wound healing |
| response to hexose |
| response to monosaccharide |
| regeneration |
| regulation of response to wounding |
| response to carbohydrate |
| response to temperature stimulus |
| glucose homeostasis |
| carbohydrate homeostasis |
| regulation of animal organ morphogenesis |
| blood coagulation |
| coagulation |
| hemostasis |
| regulation of epithelial cell proliferation |
| negative regulation of proteolysis |
| negative regulation of response to external stimulus |
| positive regulation of secretion by cell |
| gland development |
| positive regulation of secretion |
| regulation of immune effector process |
| wound healing |
| regulation of body fluid levels |
| response to wounding |
| positive regulation of response to external stimulus |
| negative regulation of cell population proliferation |
| regulation of proteolysis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of secretion |
| zinc ion binding |
| cellular homeostasis |
| negative regulation of developmental process |
| positive regulation of transport |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| regulation of immune response |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of response to stress |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Betulinic acid 10 to 15μM on day4 R05 exp222 | -1.92 |
| SGC2043 10μM R03 exp152 | -1.71 |
| Beta-Estradiol 0.55μM R07 exp425 | 2.19 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15933
- Expression level (log2 read counts): 0.19
Expression Distribution
CPB2 Expression in NALM6 Cells: 0.19
