CRTAM
Gene Information
- Official Symbol: CRTAM
- Official Name: cytotoxic and regulatory T cell molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 56253
- UniProt: O95727
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.
Pfam Domains GO Terms
Pfam Domains
| V-set |
| C2-set 2 |
| I-set |
GO Terms
| detection of tumor cell |
| positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| activated T cell proliferation |
| positive regulation of natural killer cell mediated immune response to tumor cell |
| regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| regulation of natural killer cell mediated immune response to tumor cell |
| response to tumor cell |
| positive regulation of immune response to tumor cell |
| positive regulation of response to tumor cell |
| regulation of immune response to tumor cell |
| regulation of response to tumor cell |
| T cell mediated cytotoxicity |
| detection of biotic stimulus |
| positive regulation of natural killer cell mediated cytotoxicity |
| positive regulation of natural killer cell mediated immunity |
| T cell proliferation |
| leukocyte mediated cytotoxicity |
| T cell mediated immunity |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of cell killing |
| regulation of leukocyte mediated cytotoxicity |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| cell killing |
| leukocyte proliferation |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of leukocyte mediated immunity |
| positive regulation of cytokine secretion |
| regulation of lymphocyte mediated immunity |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| positive regulation of immune effector process |
| T cell activation |
| cell recognition |
| lymphocyte mediated immunity |
| positive regulation of protein secretion |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of peptide secretion |
| signaling receptor binding |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| cell population proliferation |
| positive regulation of response to external stimulus |
| adaptive immune response |
| detection of stimulus |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| regulation of secretion |
| positive regulation of immune response |
| leukocyte activation |
| positive regulation of transport |
| regulation of protein localization |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| response to biotic stimulus |
| regulation of response to stress |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UNC1999 2μM R03 exp155 | 1.72 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.412 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11922
- Expression level (log2 read counts): 1.84
Expression Distribution
CRTAM Expression in NALM6 Cells: 1.84
