CSTF2
Gene Information
- Official Symbol: CSTF2
- Official Name: cleavage stimulation factor subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1478
- UniProt: P33240
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008].
- UniProt Summary: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:9199325}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6304
- Expression level (log2 read counts): 5.34
CSTF2 Expression in NALM6 Cells: 5.34
