DACT2
Gene Information
- Official Symbol: DACT2
- Official Name: dishevelled binding antagonist of beta catenin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 168002
- UniProt: Q5SW24
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5233
- Expression level (log2 read counts): -7.68
DACT2 Expression in NALM6 Cells: -7.68
