Entrez Summary: The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
C-C chemokine binding
regulation of chemokine production
chemokine-mediated signaling pathway
cellular response to chemokine
response to chemokine
recycling endosome
transmembrane signaling receptor activity
signaling receptor activity
early endosome
inflammatory response
cytokine-mediated signaling pathway
regulation of cytokine production
G protein-coupled receptor activity
cellular response to cytokine stimulus
response to cytokine
G protein-coupled receptor signaling pathway
defense response
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739