UniProt Summary: Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.
Pfam DomainsGO Terms
Pfam Domains
Defensin propep
Defensin 1
GO Terms
membrane disruption in other organism
innate immune response in mucosa
mucosal immune response
organ or tissue specific immune response
defense response to fungus
antibacterial humoral response
response to fungus
killing of cells of other organism
disruption of cells of other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
defense response to Gram-negative bacterium
cell killing
defense response to Gram-positive bacterium
Golgi lumen
antimicrobial humoral response
modification of morphology or physiology of other organism
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
humoral immune response
cellular response to lipid
response to bacterium
innate immune response
interspecies interaction between organisms
response to lipid
protein homodimerization activity
defense response to other organism
cellular response to oxygen-containing compound
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
response to oxygen-containing compound
extracellular space
immune response
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)