DEFB104A
Gene Information
- Official Symbol: DEFB104A
- Official Name: defensin beta 104A
- Aliases and Previous Symbols: N/A
- Entrez ID: 140596
- UniProt: Q8WTQ1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Oct 2014].
- UniProt Summary: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. {ECO:0000269|PubMed:11481241}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18321
- Expression level (log2 read counts): -7.68
DEFB104A Expression in NALM6 Cells: -7.68
