DKK4
Gene Information
- Official Symbol: DKK4
- Official Name: dickkopf WNT signaling pathway inhibitor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 27121
- UniProt: Q9UBT3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18300
- Expression level (log2 read counts): -6.6
DKK4 Expression in NALM6 Cells: -6.6
