DNM3
Gene Information
- Official Symbol: DNM3
- Official Name: dynamin 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 26052
- UniProt: Q9UQ16
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Dynamin N |
| PH |
| GED |
| Dynamin M |
GO Terms
| type 1 metabotropic glutamate receptor binding |
| basal tubulobulbar complex |
| apical tubulobulbar complex |
| structural constituent of postsynapse |
| postsynaptic endocytic zone membrane |
| synaptic vesicle budding from presynaptic endocytic zone membrane |
| type 5 metabotropic glutamate receptor binding |
| postsynaptic endocytosis |
| postsynaptic neurotransmitter receptor internalization |
| negative regulation of dendritic spine morphogenesis |
| synaptic vesicle budding |
| dendritic spine head |
| positive regulation of synaptic vesicle recycling |
| neurotransmitter receptor internalization |
| negative regulation of dendritic spine development |
| synaptic cleft |
| nitric-oxide synthase binding |
| negative regulation of dendrite morphogenesis |
| filopodium assembly |
| negative regulation of synapse organization |
| regulation of synaptic vesicle recycling |
| negative regulation of dendrite development |
| positive regulation of filopodium assembly |
| neurotransmitter receptor transport |
| synaptic vesicle transport |
| synaptic vesicle localization |
| regulation of dendritic spine morphogenesis |
| synaptic vesicle endocytosis |
| presynaptic endocytosis |
| regulation of filopodium assembly |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| photoreceptor inner segment |
| synaptic vesicle recycling |
| receptor internalization |
| regulation of dendritic spine development |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| synapse assembly |
| presynapse |
| vesicle budding from membrane |
| regulation of postsynapse organization |
| negative regulation of cell morphogenesis involved in differentiation |
| positive regulation of plasma membrane bounded cell projection assembly |
| receptor metabolic process |
| regulation of synaptic vesicle cycle |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| dendritic spine |
| regulation of dendrite development |
| negative regulation of neuron projection development |
| establishment of vesicle localization |
| negative regulation of cell projection organization |
| vesicle localization |
| regulation of plasma membrane bounded cell projection assembly |
| postsynaptic membrane |
| regulation of cell projection assembly |
| regulation of synapse organization |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| receptor-mediated endocytosis |
| microtubule binding |
| postsynaptic density |
| cytoplasmic vesicle |
| protein-containing complex localization |
| synapse |
| synapse organization |
| negative regulation of neurogenesis |
| axon |
| vesicle organization |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| microtubule |
| GTPase activity |
| negative regulation of cell development |
| glutamatergic synapse |
| establishment of organelle localization |
| positive regulation of cell projection organization |
| GTP binding |
| establishment of protein localization to organelle |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| positive regulation of cellular component biogenesis |
| regulation of vesicle-mediated transport |
| endocytosis |
| organelle localization |
| regulation of neuron differentiation |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| protein localization to organelle |
| regulation of neurogenesis |
| membrane organization |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| Golgi apparatus |
| positive regulation of transport |
| regulation of anatomical structure morphogenesis |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| protein transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Prochlorperazine 5.2μM R02 exp77 | 1.74 |
| INK128 0.2μM R02 exp70 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5628
- Expression level (log2 read counts): -0.9
Expression Distribution
DNM3 Expression in NALM6 Cells: -0.9
