DPH7
Gene Information
- Official Symbol: DPH7
- Official Name: diphthamide biosynthesis 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 92715
- UniProt: Q9BTV6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016].
- UniProt Summary: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250|UniProtKB:P38332, ECO:0000269|PubMed:19965467, ECO:0000269|PubMed:23486472}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4931
- Expression level (log2 read counts): 5.42
DPH7 Expression in NALM6 Cells: 5.42
