DPY30
Gene Information
- Official Symbol: DPY30
- Official Name: dpy-30 histone methyltransferase complex regulatory subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 84661
- UniProt: Q9C005
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 792
- Expression level (log2 read counts): 5.02
DPY30 Expression in NALM6 Cells: 5.02
