DRD1
Gene Information
- Official Symbol: DRD1
- Official Name: dopamine receptor D1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1812
- UniProt: P21728
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
| 7TM GPCR Srx |
GO Terms
| sensitization |
| dopamine neurotransmitter receptor activity, coupled via Gs |
| dopamine neurotransmitter receptor activity |
| operant conditioning |
| habituation |
| histone H3-S10 phosphorylation |
| conditioned taste aversion |
| nonassociative learning |
| interneuron migration |
| cerebral cortex GABAergic interneuron migration |
| cerebral cortex GABAergic interneuron development |
| phospholipase C-activating dopamine receptor signaling pathway |
| glucose import |
| regulation of catecholamine uptake involved in synaptic transmission |
| regulation of dopamine uptake involved in synaptic transmission |
| interneuron migration from the subpallium to the cortex |
| peristalsis |
| adenylate cyclase-activating dopamine receptor signaling pathway |
| histone-serine phosphorylation |
| dopamine transport |
| cerebral cortex GABAergic interneuron differentiation |
| substrate-independent telencephalic tangential migration |
| substrate-independent telencephalic tangential interneuron migration |
| parental behavior |
| maternal behavior |
| dopamine binding |
| catecholamine transport |
| grooming behavior |
| GABAergic neuron differentiation |
| prepulse inhibition |
| regulation of synaptic transmission, dopaminergic |
| dentate gyrus development |
| long-term synaptic depression |
| phasic smooth muscle contraction |
| striatum development |
| synaptic transmission, dopaminergic |
| regulation of neurotransmitter uptake |
| regulation of catecholamine metabolic process |
| regulation of dopamine metabolic process |
| behavioral response to cocaine |
| mating behavior |
| monoamine transport |
| cerebral cortex neuron differentiation |
| subpallium development |
| G-protein alpha-subunit binding |
| startle response |
| dopamine metabolic process |
| reproductive behavior |
| neuronal action potential |
| histone phosphorylation |
| adult walking behavior |
| behavioral fear response |
| vasodilation |
| temperature homeostasis |
| forebrain neuron development |
| walking behavior |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| behavioral defense response |
| positive regulation of synaptic transmission, glutamatergic |
| response to amphetamine |
| non-motile cilium |
| glucose transmembrane transport |
| mating |
| fear response |
| dopamine receptor signaling pathway |
| hexose transmembrane transport |
| astrocyte development |
| monosaccharide transmembrane transport |
| carbohydrate transmembrane transport |
| activation of adenylate cyclase activity |
| positive regulation of release of sequestered calcium ion into cytosol |
| catecholamine metabolic process |
| catechol-containing compound metabolic process |
| integral component of postsynaptic membrane |
| positive regulation of potassium ion transport |
| response to amine |
| long-term synaptic potentiation |
| visual learning |
| response to bronchodilator |
| forebrain neuron differentiation |
| ammonium transport |
| smooth muscle contraction |
| astrocyte differentiation |
| visual behavior |
| ciliary membrane |
| positive regulation of calcium ion transport into cytosol |
| response to cocaine |
| transmission of nerve impulse |
| positive regulation of blood vessel diameter |
| telencephalon cell migration |
| integral component of presynaptic membrane |
| forebrain cell migration |
| negative regulation of synaptic transmission |
| forebrain generation of neurons |
| GABA-ergic synapse |
| multicellular organismal response to stress |
| regulation of synaptic transmission, glutamatergic |
| positive regulation of calcium ion transmembrane transport |
| carbohydrate transport |
| adult locomotory behavior |
| regulation of release of sequestered calcium ion into cytosol |
| associative learning |
| response to anesthetic |
| regulation of synaptic vesicle exocytosis |
| regulation of cellular amine metabolic process |
| central nervous system neuron development |
| hippocampus development |
| phenol-containing compound metabolic process |
| cellular response to dopamine |
| feeding behavior |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| synapse assembly |
| regulation of amine transport |
| action potential |
| protein import into nucleus |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of potassium ion transport |
| regulation of calcium ion transport into cytosol |
| regulation of response to drug |
| cellular response to catecholamine stimulus |
| cellular response to monoamine stimulus |
| regulation of neurotransmitter secretion |
| response to catecholamine |
| response to monoamine |
| glial cell development |
| neuromuscular process |
| limbic system development |
| regulation of synaptic vesicle cycle |
| response to alkaloid |
| import into nucleus |
| memory |
| neuron migration |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| cellular response to ammonium ion |
| multicellular organismal signaling |
| organic hydroxy compound transport |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| protein import |
| positive regulation of cation transmembrane transport |
| regulation of neurotransmitter transport |
| adult behavior |
| learning |
| cAMP-mediated signaling |
| regulation of calcium ion transmembrane transport |
| drug transport |
| dendritic spine |
| positive regulation of synaptic transmission |
| positive regulation of ion transmembrane transport |
| protein localization to nucleus |
| regulation of regulated secretory pathway |
| vascular process in circulatory system |
| glial cell differentiation |
| cyclic-nucleotide-mediated signaling |
| pallium development |
| peptidyl-serine phosphorylation |
| central nervous system neuron differentiation |
| response to ammonium ion |
| regulation of synaptic plasticity |
| ammonium ion metabolic process |
| locomotory behavior |
| peptidyl-serine modification |
| cilium |
| positive regulation of transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| gliogenesis |
| regulation of exocytosis |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| muscle contraction |
| telencephalon development |
| learning or memory |
| nucleocytoplasmic transport |
| nuclear transport |
| synapse organization |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| cognition |
| muscle system process |
| response to xenobiotic stimulus |
| response to light stimulus |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| histone modification |
| negative regulation of response to external stimulus |
| covalent chromatin modification |
| forebrain development |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| regulation of membrane potential |
| establishment of protein localization to organelle |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| organic hydroxy compound metabolic process |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| drug metabolic process |
| positive regulation of cell migration |
| response to toxic substance |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| behavior |
| cellular response to organonitrogen compound |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| chromatin organization |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| protein localization to organelle |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| head development |
| ion homeostasis |
| regulation of secretion |
| neuron development |
| multicellular organismal reproductive process |
| cation transport |
| sexual reproduction |
| multicellular organism reproduction |
| regulation of cell migration |
| peptidyl-amino acid modification |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cell migration |
| protein phosphorylation |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| multi-organism reproductive process |
| regulation of cellular component movement |
| intracellular protein transport |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| cellular response to oxygen-containing compound |
| chromosome organization |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| transmembrane transport |
| phosphorylation |
| locomotion |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM131593 0.1μM R01 exp58 | 1.72 |
| Pyrazinamide 100μM R08 exp516 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10276
- Expression level (log2 read counts): -7.68
Expression Distribution
DRD1 Expression in NALM6 Cells: -7.68
