DUSP9
Gene Information
- Official Symbol: DUSP9
- Official Name: dual specificity phosphatase 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 1852
- UniProt: Q99956
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inactivates MAP kinases. Has a specificity for the ERK family.
Pfam Domains GO Terms
Pfam Domains
| Rhodanese |
| DSPc |
GO Terms
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| inactivation of MAPK activity |
| phosphoprotein phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| negative regulation of MAP kinase activity |
| JNK cascade |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| stress-activated MAPK cascade |
| negative regulation of protein serine/threonine kinase activity |
| stress-activated protein kinase signaling cascade |
| activation of MAPK activity |
| negative regulation of MAPK cascade |
| protein dephosphorylation |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| positive regulation of MAP kinase activity |
| negative regulation of transferase activity |
| dephosphorylation |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| positive regulation of transferase activity |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13541
- Expression level (log2 read counts): -3.35
Expression Distribution
DUSP9 Expression in NALM6 Cells: -3.35
