DVL2
Gene Information
- Official Symbol: DVL2
- Official Name: dishevelled segment polarity protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1856
- UniProt: O14641
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}.
Pfam Domains GO Terms
Pfam Domains
| Dsh C |
| DEP |
| Dishevelled |
| PDZ |
| DIX |
GO Terms
| neural plate elongation |
| convergent extension involved in neural plate elongation |
| canonical Wnt signaling pathway involved in regulation of cell proliferation |
| convergent extension involved in organogenesis |
| neural plate morphogenesis |
| positive regulation of neuron projection arborization |
| convergent extension involved in gastrulation |
| neural plate development |
| regulation of neuron projection arborization |
| planar cell polarity pathway involved in neural tube closure |
| convergent extension |
| regulation of establishment of planar polarity involved in neural tube closure |
| segment specification |
| regulation of epithelial tube formation |
| beta-catenin destruction complex disassembly |
| cochlea morphogenesis |
| clathrin-coated endocytic vesicle |
| hippo signaling |
| frizzled binding |
| aggresome |
| morphogenesis of an epithelial sheet |
| cochlea development |
| Rac GTPase binding |
| positive regulation of protein tyrosine kinase activity |
| protein self-association |
| lateral plasma membrane |
| apical part of cell |
| positive regulation of JUN kinase activity |
| outflow tract morphogenesis |
| protein binding, bridging |
| regulation of JUN kinase activity |
| regulation of protein tyrosine kinase activity |
| canonical Wnt signaling pathway |
| neural tube closure |
| tube closure |
| segmentation |
| Wnt signaling pathway, planar cell polarity pathway |
| inner ear morphogenesis |
| primary neural tube formation |
| neural tube formation |
| regulation of establishment of planar polarity |
| ear morphogenesis |
| embryonic epithelial tube formation |
| regulation of embryonic development |
| epithelial tube formation |
| non-canonical Wnt signaling pathway |
| positive regulation of JNK cascade |
| morphogenesis of embryonic epithelium |
| tube formation |
| gastrulation |
| neural tube development |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| negative regulation of canonical Wnt signaling pathway |
| regulation of morphogenesis of an epithelium |
| regulation of JNK cascade |
| positive regulation of peptidyl-tyrosine phosphorylation |
| inner ear development |
| negative regulation of Wnt signaling pathway |
| ear development |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein-containing complex disassembly |
| protein domain specific binding |
| heart morphogenesis |
| regulation of peptidyl-tyrosine phosphorylation |
| cytoplasmic vesicle |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of MAP kinase activity |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of neuron projection development |
| regulation of canonical Wnt signaling pathway |
| nuclear body |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| regionalization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| cellular component disassembly |
| positive regulation of GTPase activity |
| regulation of DNA-binding transcription factor activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| protein kinase binding |
| positive regulation of neurogenesis |
| transcription by RNA polymerase II |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| regulation of protein serine/threonine kinase activity |
| protein complex oligomerization |
| heart development |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| sensory organ development |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| tube development |
| membrane organization |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2961
- Expression level (log2 read counts): 5.9
Expression Distribution
DVL2 Expression in NALM6 Cells: 5.9
