EEF2K
Gene Information
- Official Symbol: EEF2K
- Official Name: eukaryotic elongation factor 2 kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 29904
- UniProt: O00418
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.
Pfam Domains GO Terms
Pfam Domains
| Alpha kinase |
GO Terms
| cellular response to anoxia |
| elongation factor-2 kinase activity |
| response to anoxia |
| response to prolactin |
| cellular response to brain-derived neurotrophic factor stimulus |
| positive regulation of dendritic spine morphogenesis |
| translation factor activity, RNA binding |
| positive regulation of dendrite morphogenesis |
| regulation of dendritic spine morphogenesis |
| positive regulation of dendritic spine development |
| regulation of protein autophosphorylation |
| cellular response to nerve growth factor stimulus |
| response to ischemia |
| response to nerve growth factor |
| cellular response to cAMP |
| positive regulation of synapse assembly |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| cellular response to calcium ion |
| regulation of dendrite morphogenesis |
| regulation of postsynapse organization |
| response to cAMP |
| positive regulation of endocytosis |
| regulation of synapse assembly |
| translational elongation |
| response to organophosphorus |
| dendritic spine |
| regulation of dendrite development |
| response to calcium ion |
| response to purine-containing compound |
| positive regulation of cell morphogenesis involved in differentiation |
| cellular response to insulin stimulus |
| cellular response to metal ion |
| protein autophosphorylation |
| cellular response to decreased oxygen levels |
| calmodulin binding |
| regulation of endocytosis |
| cellular response to oxygen levels |
| regulation of synapse organization |
| cellular response to inorganic substance |
| regulation of synapse structure or activity |
| response to insulin |
| protein kinase activity |
| postsynaptic density |
| cellular response to peptide hormone stimulus |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| cellular response to peptide |
| response to decreased oxygen levels |
| positive regulation of neuron differentiation |
| response to metal ion |
| response to oxygen levels |
| positive regulation of cell projection organization |
| translation |
| response to peptide hormone |
| peptide biosynthetic process |
| positive regulation of neurogenesis |
| response to peptide |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| positive regulation of cellular component biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| response to growth factor |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| calcium ion binding |
| cellular amide metabolic process |
| regulation of neurogenesis |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| positive regulation of transport |
| negative regulation of cell death |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| phosphorylation |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| generation of neurons |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13832
- Expression level (log2 read counts): 6.79
Expression Distribution
EEF2K Expression in NALM6 Cells: 6.79
