Pfam Domains GO Terms
| negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| negative regulation of transcription regulatory region DNA binding |
| negative regulation of insulin receptor signaling pathway |
| negative regulation of cellular response to insulin stimulus |
| negative regulation of insulin secretion |
| negative regulation of peptide hormone secretion |
| negative regulation of lipid biosynthetic process |
| regulation of transcription regulatory region DNA binding |
| positive regulation of Notch signaling pathway |
| negative regulation of DNA binding |
| negative regulation of hormone secretion |
| regulation of insulin receptor signaling pathway |
| regulation of cellular response to insulin stimulus |
| negative regulation of lipid metabolic process |
| hormone activity |
| regulation of Notch signaling pathway |
| regulation of DNA binding |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| negative regulation of binding |
| regulation of insulin secretion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of lipid biosynthetic process |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| negative regulation of secretion |
| regulation of hormone secretion |
| regulation of binding |
| regulation of lipid metabolic process |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of hormone levels |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of protein localization |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of biosynthetic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution