EREG
Gene Information
- Official Symbol: EREG
- Official Name: epiregulin
- Aliases and Previous Symbols: N/A
- Entrez ID: 2069
- UniProt: O14944
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| primary follicle stage |
| luteinizing hormone signaling pathway |
| ovarian cumulus expansion |
| fused antrum stage |
| mammalian oogenesis stage |
| antral ovarian follicle growth |
| positive regulation of epidermal growth factor-activated receptor activity |
| keratinocyte proliferation |
| positive regulation of interleukin-6 biosynthetic process |
| negative regulation of smooth muscle cell differentiation |
| ovulation |
| oocyte maturation |
| regulation of interleukin-6 biosynthetic process |
| mRNA transcription |
| regulation of epidermal growth factor-activated receptor activity |
| positive regulation of epidermal growth factor receptor signaling pathway |
| female meiotic nuclear division |
| regulation of smooth muscle cell differentiation |
| ERBB2 signaling pathway |
| positive regulation of ERBB signaling pathway |
| epidermal growth factor receptor binding |
| positive regulation of signaling receptor activity |
| positive regulation of DNA replication |
| oocyte development |
| ovulation cycle process |
| oocyte differentiation |
| negative regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of fibroblast proliferation |
| epidermal growth factor receptor signaling pathway |
| ovarian follicle development |
| negative regulation of ERBB signaling pathway |
| positive regulation of mitotic nuclear division |
| clathrin-coated vesicle membrane |
| negative regulation of muscle cell differentiation |
| positive regulation of protein tyrosine kinase activity |
| positive regulation of nuclear division |
| positive regulation of cytokine biosynthetic process |
| ovulation cycle |
| ERBB signaling pathway |
| oogenesis |
| regulation of fibroblast proliferation |
| regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of cell division |
| epithelial cell proliferation |
| female gonad development |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| development of primary female sexual characteristics |
| positive regulation of interleukin-6 production |
| regulation of cytokine biosynthetic process |
| female sex differentiation |
| regulation of DNA replication |
| negative regulation of epithelial cell proliferation |
| female gamete generation |
| regulation of smooth muscle cell proliferation |
| anatomical structure maturation |
| regulation of interleukin-6 production |
| positive regulation of mitotic cell cycle |
| meiotic nuclear division |
| regulation of muscle cell differentiation |
| cell maturation |
| growth factor activity |
| meiotic cell cycle process |
| positive regulation of protein kinase B signaling |
| regulation of cell division |
| regulation of mitotic nuclear division |
| regulation of signaling receptor activity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of nuclear division |
| gonad development |
| development of primary sexual characteristics |
| regulation of protein kinase B signaling |
| meiotic cell cycle |
| developmental maturation |
| regulation of peptidyl-tyrosine phosphorylation |
| germ cell development |
| sex differentiation |
| keratinocyte differentiation |
| rhythmic process |
| nuclear division |
| positive regulation of cell cycle process |
| organelle fission |
| epidermal cell differentiation |
| angiogenesis |
| regulation of epithelial cell proliferation |
| positive regulation of innate immune response |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of response to biotic stimulus |
| MAPK cascade |
| positive regulation of cell cycle |
| skin development |
| developmental growth |
| response to peptide hormone |
| growth |
| signal transduction by protein phosphorylation |
| blood vessel morphogenesis |
| epidermis development |
| reproductive structure development |
| reproductive system development |
| positive regulation of cytokine production |
| regulation of innate immune response |
| response to peptide |
| positive regulation of defense response |
| wound healing |
| blood vessel development |
| positive regulation of multi-organism process |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cardiovascular system development |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| cell population proliferation |
| response to wounding |
| positive regulation of kinase activity |
| positive regulation of response to external stimulus |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| tube morphogenesis |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| gamete generation |
| mRNA metabolic process |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cell cycle process |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| membrane organization |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| cell cycle process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5248
- Expression level (log2 read counts): 3.08
Expression Distribution
EREG Expression in NALM6 Cells: 3.08
