EVL
Gene Information
- Official Symbol: EVL
- Official Name: Enah/Vasp-like
- Aliases and Previous Symbols: N/A
- Entrez ID: 51466
- UniProt: Q9UI08
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Pfam Domains GO Terms
Pfam Domains
| WH1 |
| VASP tetra |
| VASP |
GO Terms
| negative regulation of ruffle assembly |
| profilin binding |
| negative regulation of plasma membrane bounded cell projection assembly |
| regulation of ruffle assembly |
| actin nucleation |
| actin polymerization or depolymerization |
| positive regulation of stress fiber assembly |
| phagocytic vesicle |
| positive regulation of actin filament bundle assembly |
| negative regulation of epithelial cell migration |
| regulation of stress fiber assembly |
| regulation of actomyosin structure organization |
| positive regulation of actin filament polymerization |
| regulation of actin filament bundle assembly |
| protein homotetramerization |
| positive regulation of protein polymerization |
| SH3 domain binding |
| protein tetramerization |
| cellular response to interferon-gamma |
| regulation of actin filament polymerization |
| lamellipodium |
| response to interferon-gamma |
| negative regulation of cell projection organization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of epithelial cell migration |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| positive regulation of protein complex assembly |
| negative regulation of cell migration |
| axon guidance |
| regulation of actin filament organization |
| neuron projection guidance |
| actin binding |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| protein homooligomerization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| axonogenesis |
| regulation of cellular component size |
| regulation of actin filament-based process |
| axon development |
| focal adhesion |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| cell part morphogenesis |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| actin filament-based process |
| positive regulation of organelle organization |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| cell morphogenesis |
| innate immune response |
| neuron development |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of cell motility |
| defense response to other organism |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| neuron differentiation |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| generation of neurons |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| neurogenesis |
| cell development |
| protein-containing complex subunit organization |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4531
- Expression level (log2 read counts): 6.54
Expression Distribution
EVL Expression in NALM6 Cells: 6.54
