FAM35A
Gene Information
- Official Symbol: SHLD2
- Official Name: shieldin complex subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 54537
- UniProt: Q86V20
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of double-strand break repair via nonhomologous end joining |
| negative regulation of double-strand break repair via homologous recombination |
| regulation of double-strand break repair via nonhomologous end joining |
| positive regulation of isotype switching |
| negative regulation of double-strand break repair |
| positive regulation of double-strand break repair |
| regulation of isotype switching |
| negative regulation of DNA repair |
| positive regulation of B cell mediated immunity |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of DNA recombination |
| positive regulation of immunoglobulin production |
| negative regulation of DNA recombination |
| regulation of double-strand break repair via homologous recombination |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| site of double-strand break |
| regulation of immunoglobulin production |
| positive regulation of DNA repair |
| regulation of double-strand break repair |
| negative regulation of response to DNA damage stimulus |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of response to DNA damage stimulus |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of DNA recombination |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| negative regulation of DNA metabolic process |
| chromosome |
| regulation of DNA repair |
| positive regulation of leukocyte mediated immunity |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| regulation of adaptive immune response |
| positive regulation of B cell activation |
| positive regulation of DNA metabolic process |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of response to DNA damage stimulus |
| positive regulation of immune effector process |
| regulation of DNA metabolic process |
| positive regulation of lymphocyte activation |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of immune effector process |
| DNA repair |
| regulation of lymphocyte activation |
| regulation of leukocyte activation |
| regulation of cell activation |
| regulation of cellular response to stress |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| positive regulation of immune response |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of developmental process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of response to stress |
| negative regulation of response to stimulus |
| regulation of immune system process |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Genistein 15μM R07 exp360 | -2.17 |
| Dorsomorphin 5μM R07 exp357 | -1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6852
- Expression level (log2 read counts): 6.2
Expression Distribution
FAM35A Expression in NALM6 Cells: 6.2
