FASN
Gene Information
- Official Symbol: FASN
- Official Name: fatty acid synthase
- Aliases and Previous Symbols: N/A
- Entrez ID: 2194
- UniProt: P49327
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Acyl transf 1 |
| ketoacyl-synt |
| KR |
| PP-binding |
| Methyltransf 12 |
| adh short |
| Ketoacyl-synt C |
| ADH zinc N |
| Thioesterase |
GO Terms
| phosphopantetheine binding |
| 3-oxo-pimeloyl-[acp] methyl ester reductase activity |
| enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity |
| 3-oxo-glutaryl-[acp] methyl ester reductase activity |
| (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity |
| 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| [acyl-carrier-protein] S-acetyltransferase activity |
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| oleoyl-[acyl-carrier-protein] hydrolase activity |
| myristoyl-[acyl-carrier-protein] hydrolase activity |
| [acyl-carrier-protein] S-malonyltransferase activity |
| palmitoyl-[acyl-carrier-protein] hydrolase activity |
| ether biosynthetic process |
| glycerol ether biosynthetic process |
| ether lipid biosynthetic process |
| neutrophil differentiation |
| glycogen granule |
| cellular lipid biosynthetic process |
| ether lipid metabolic process |
| glycerol ether metabolic process |
| establishment of endothelial intestinal barrier |
| NADPH binding |
| ether metabolic process |
| mononuclear cell differentiation |
| monocyte differentiation |
| granulocyte differentiation |
| cellular response to interleukin-4 |
| acetyl-CoA metabolic process |
| response to interleukin-4 |
| establishment of endothelial barrier |
| fatty-acyl-CoA biosynthetic process |
| fatty-acyl-CoA metabolic process |
| regulation of sterol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| acyl-CoA biosynthetic process |
| thioester biosynthetic process |
| endothelial cell development |
| regulation of cholesterol metabolic process |
| drug binding |
| purine nucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| ribonucleoside bisphosphate biosynthetic process |
| regulation of alcohol biosynthetic process |
| endothelial cell differentiation |
| regulation of steroid biosynthetic process |
| fatty acid derivative biosynthetic process |
| endothelium development |
| acyl-CoA metabolic process |
| thioester metabolic process |
| melanosome |
| myeloid leukocyte differentiation |
| regulation of steroid metabolic process |
| fatty acid biosynthetic process |
| osteoblast differentiation |
| mammary gland development |
| nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| epithelial cell development |
| cofactor biosynthetic process |
| myeloid cell differentiation |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| ossification |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| cadherin binding |
| purine ribonucleotide metabolic process |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| leukocyte differentiation |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| regulation of lipid metabolic process |
| gland development |
| regulation of small molecule metabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| hemopoiesis |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| hematopoietic or lymphoid organ development |
| carbohydrate derivative biosynthetic process |
| immune system development |
| epithelial cell differentiation |
| cellular amide metabolic process |
| protein homodimerization activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| oxidation-reduction process |
| Golgi apparatus |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| epithelium development |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cell development |
| small molecule metabolic process |
| tissue development |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus Deferoxamine 11μM R07 exp321 | 1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 20/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2224
- Expression level (log2 read counts): 9.08
Expression Distribution
FASN Expression in NALM6 Cells: 9.08
