FGD1
Gene Information
- Official Symbol: FGD1
- Official Name: FYVE, RhoGEF and PH domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2245
- UniProt: P98174
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017].
- UniProt Summary: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10842
- Expression level (log2 read counts): 2.19
FGD1 Expression in NALM6 Cells: 2.19
