FGF2
Gene Information
- Official Symbol: FGF2
- Official Name: fibroblast growth factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2247
- UniProt: P09038
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| FGF |
GO Terms
| growth factor dependent regulation of skeletal muscle satellite cell proliferation |
| positive regulation of cell fate specification |
| receptor-receptor interaction |
| positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| positive regulation of cell chemotaxis to fibroblast growth factor |
| chondroblast differentiation |
| paracrine signaling |
| regulation of endothelial cell chemotaxis to fibroblast growth factor |
| regulation of cell chemotaxis to fibroblast growth factor |
| negative regulation of fibroblast migration |
| positive regulation of cell fate commitment |
| regulation of cell fate specification |
| regulation of skeletal muscle satellite cell proliferation |
| regulation of skeletal muscle cell proliferation |
| positive regulation of vascular endothelial cell proliferation |
| positive regulation of endothelial cell chemotaxis |
| hyaluronan catabolic process |
| regulation of vascular endothelial cell proliferation |
| regulation of endothelial cell chemotaxis |
| cell migration involved in sprouting angiogenesis |
| positive regulation of cell migration involved in sprouting angiogenesis |
| fibroblast growth factor receptor binding |
| positive regulation of cardiac muscle cell proliferation |
| inositol phosphate biosynthetic process |
| regulation of cell fate commitment |
| regulation of fibroblast migration |
| blood vessel endothelial cell migration |
| hyaluronan metabolic process |
| negative regulation of blood vessel endothelial cell migration |
| positive regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of vascular smooth muscle cell proliferation |
| positive regulation of cardiac muscle tissue growth |
| chemoattractant activity |
| positive regulation of lipid kinase activity |
| positive regulation of heart growth |
| regulation of cell migration involved in sprouting angiogenesis |
| positive regulation of sprouting angiogenesis |
| regulation of cardiac muscle cell proliferation |
| positive regulation of phospholipase C activity |
| positive regulation of cardiac muscle tissue development |
| branching involved in ureteric bud morphogenesis |
| regulation of phospholipase C activity |
| positive regulation of phospholipid metabolic process |
| positive chemotaxis |
| positive regulation of organ growth |
| negative regulation of endothelial cell migration |
| regulation of vascular smooth muscle cell proliferation |
| ureteric bud morphogenesis |
| regulation of phosphatidylinositol 3-kinase activity |
| stem cell proliferation |
| mesonephric tubule morphogenesis |
| positive regulation of blood vessel endothelial cell migration |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| inositol phosphate metabolic process |
| sprouting angiogenesis |
| regulation of cardiac muscle tissue growth |
| polyol biosynthetic process |
| positive regulation of phospholipase activity |
| glycosaminoglycan catabolic process |
| regulation of lipid kinase activity |
| nephron tubule morphogenesis |
| regulation of heart growth |
| nuclear receptor transcription coactivator activity |
| somatic stem cell population maintenance |
| endothelial cell migration |
| negative regulation of epithelial cell migration |
| aminoglycan catabolic process |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| positive regulation of DNA biosynthetic process |
| calcium ion transmembrane import into cytosol |
| renal tubule morphogenesis |
| regulation of sprouting angiogenesis |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| negative regulation of wound healing |
| calcium ion transport into cytosol |
| nephron tubule development |
| regulation of cardiac muscle tissue development |
| renal tubule development |
| fibroblast growth factor receptor signaling pathway |
| epithelial cell migration |
| regulation of phospholipid metabolic process |
| kidney morphogenesis |
| positive regulation of smooth muscle cell proliferation |
| negative regulation of response to wounding |
| ureteric bud development |
| mesonephric tubule development |
| epithelium migration |
| positive regulation of cell division |
| mesonephric epithelium development |
| cytosolic calcium ion transport |
| regulation of blood vessel endothelial cell migration |
| mesonephros development |
| tissue migration |
| positive regulation of endothelial cell proliferation |
| regulation of organ growth |
| nephron epithelium development |
| regulation of lipase activity |
| positive regulation of endothelial cell migration |
| mucopolysaccharide metabolic process |
| cellular response to fibroblast growth factor stimulus |
| phosphatidylinositol biosynthetic process |
| polyol metabolic process |
| alcohol biosynthetic process |
| regulation of DNA biosynthetic process |
| response to fibroblast growth factor |
| nephron development |
| regulation of sequestering of calcium ion |
| kidney epithelium development |
| regulation of endothelial cell proliferation |
| branching morphogenesis of an epithelial tube |
| integrin binding |
| regulation of striated muscle tissue development |
| regulation of smooth muscle cell proliferation |
| regulation of muscle tissue development |
| stem cell population maintenance |
| positive regulation of chemotaxis |
| regulation of muscle organ development |
| maintenance of cell number |
| regulation of wound healing |
| positive regulation of epithelial cell migration |
| positive regulation of lipid metabolic process |
| activation of MAPK activity |
| glycosaminoglycan metabolic process |
| regulation of endothelial cell migration |
| morphogenesis of a branching epithelium |
| growth factor activity |
| positive regulation of angiogenesis |
| aminoglycan metabolic process |
| positive regulation of protein kinase B signaling |
| regulation of response to wounding |
| phosphatidylinositol metabolic process |
| regulation of cell division |
| morphogenesis of a branching structure |
| heparin binding |
| positive regulation of developmental growth |
| cartilage development |
| ameboidal-type cell migration |
| cytokine activity |
| positive regulation of vasculature development |
| organic hydroxy compound biosynthetic process |
| positive regulation of epithelial cell proliferation |
| carbohydrate derivative catabolic process |
| positive regulation of DNA metabolic process |
| calcium ion transmembrane transport |
| glycerophospholipid biosynthetic process |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| glycerolipid biosynthetic process |
| connective tissue development |
| phospholipid biosynthetic process |
| Ras protein signal transduction |
| calcium ion transport |
| positive regulation of growth |
| negative regulation of cell migration |
| positive regulation of MAP kinase activity |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| positive regulation of cytosolic calcium ion concentration |
| renal system development |
| regulation of angiogenesis |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| divalent inorganic cation transport |
| epithelial tube morphogenesis |
| glycerophospholipid metabolic process |
| negative regulation of cellular component movement |
| alcohol metabolic process |
| angiogenesis |
| urogenital system development |
| small GTPase mediated signal transduction |
| regulation of vasculature development |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| regulation of MAP kinase activity |
| regulation of DNA metabolic process |
| negative regulation of response to external stimulus |
| MAPK cascade |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| extracellular structure organization |
| signal transduction by protein phosphorylation |
| regulation of lipid metabolic process |
| blood vessel morphogenesis |
| morphogenesis of an epithelium |
| cellular calcium ion homeostasis |
| small molecule catabolic process |
| calcium ion homeostasis |
| organic hydroxy compound metabolic process |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| blood vessel development |
| divalent inorganic cation homeostasis |
| skeletal system development |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell population proliferation |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of growth |
| cytokine-mediated signaling pathway |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| cation transport |
| tube development |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| organophosphate metabolic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| ion transmembrane transport |
| animal organ morphogenesis |
| cellular lipid metabolic process |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| transmembrane transport |
| phosphorylation |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18088
- Expression level (log2 read counts): 1.3
Expression Distribution
FGF2 Expression in NALM6 Cells: 1.3
