FOXD1

Gene Information

Official Symbol: FOXD1
Official Name: forkhead box D1
Aliases and Previous Symbols: N/A
Entrez ID: 2297
UniProt: Q16676
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902). {ECO:0000250|UniProtKB:Q61345, ECO:0000269|PubMed:27805902}.

Pfam Domains GO Terms

Pfam Domains

Fork head

GO Terms

metanephric capsule development

renal capsule morphogenesis

metanephric capsule morphogenesis

metanephric capsule specification

renal capsule development

metanephric capsule formation

renal capsule specification

renal capsule formation

dichotomous subdivision of terminal units involved in ureteric bud branching

nephrogenic mesenchyme development

luteinizing hormone secretion

gonadotropin secretion

pattern specification involved in metanephros development

renal system pattern specification

pattern specification involved in kidney development

dichotomous subdivision of an epithelial terminal unit

endocrine hormone secretion

kidney mesenchyme development

DNA binding, bending

metanephric nephron development

positive regulation of BMP signaling pathway

positive regulation of kidney development

branching involved in ureteric bud morphogenesis

endocrine process

ureteric bud morphogenesis

mesonephric tubule morphogenesis

regulation of kidney development

nephron tubule morphogenesis

nephron epithelium morphogenesis

nephron morphogenesis

renal tubule morphogenesis

hormone secretion

nephron tubule development

renal tubule development

hormone transport

metanephros development

kidney morphogenesis

ureteric bud development

mesonephric tubule development

mesonephric epithelium development

regulation of BMP signaling pathway

mesonephros development

nephron epithelium development

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

nephron development

kidney epithelium development

branching morphogenesis of an epithelial tube

morphogenesis of a branching epithelium

morphogenesis of a branching structure

signal release

mesenchyme development

connective tissue development

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

axon guidance

neuron projection guidance

kidney development

regulation of cellular response to growth factor stimulus

renal system development

epithelial tube morphogenesis

urogenital system development

regionalization

axonogenesis

axon development

sequence-specific DNA binding

morphogenesis of an epithelium

cell morphogenesis involved in neuron differentiation

pattern specification process

DNA-binding transcription activator activity, RNA polymerase II-specific

neuron projection morphogenesis

plasma membrane bounded cell projection morphogenesis

cell projection morphogenesis

RNA polymerase II proximal promoter sequence-specific DNA binding

cell part morphogenesis

regulation of hormone levels

chemotaxis

taxis

cell morphogenesis involved in differentiation

tissue morphogenesis

tube morphogenesis

neuron projection development

DNA-binding transcription factor activity

cell morphogenesis

neuron development

cellular component morphogenesis

tube development

anatomical structure formation involved in morphogenesis

animal organ morphogenesis

secretion by cell

neuron differentiation

export from cell

epithelium development

cell-cell signaling

secretion

plasma membrane bounded cell projection organization

cell projection organization

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of nucleic acid-templated transcription

negative regulation of RNA biosynthetic process

locomotion

negative regulation of RNA metabolic process

positive regulation of developmental process

negative regulation of cellular macromolecule biosynthetic process

negative regulation of nucleobase-containing compound metabolic process

DNA binding

negative regulation of macromolecule biosynthetic process

negative regulation of cellular biosynthetic process

generation of neurons

positive regulation of transcription, DNA-templated

negative regulation of biosynthetic process

movement of cell or subcellular component

DNA-binding transcription factor activity, RNA polymerase II-specific

neurogenesis

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

cell development

positive regulation of signal transduction

negative regulation of gene expression

positive regulation of RNA metabolic process

positive regulation of multicellular organismal process

tissue development

positive regulation of cell communication

positive regulation of signaling

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

system process

positive regulation of cellular biosynthetic process

positive regulation of gene expression

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
5-Fluorouracil 20μM R00 exp2	-2.24
GSK591 2.6μM R03 exp128	-1.91
WYE-354 6μM R02 exp90	1.84

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: N/A

Tissue	Fraction Of Cell Lines Where Essential

Essentiality in NALM6

Essentiality Rank: 3583
Expression level (log2 read counts): -3.8

Expression Distribution